RecruitingNot ApplicableNCT07271264

A Randomised Paired Design Study of Texture and Colour Enhancement Imaging (TXI) Versus High-definition White Light Endoscopy

A Randomised Paired Design Study of Texture and Colour Enhancement Imaging (TXI) Versus High-definition White Light Endoscopy for Dysplasia Detection in IBD Surveillance.

Sponsor

London North West Healthcare NHS Trust

Enrollment

219 participants

Start Date

Dec 8, 2025

Study Type

INTERVENTIONAL

Conditions

IBD

Summary

Texture and Colour Enhancement Imaging (TXI) improves texture, brightness, and colour in white-light endoscopy to highlight subtle tissue differences. Now available through the EVIS X1 system, early evidence suggests potential value in IBD. Studies show that TXI may help predict ulcerative colitis relapse and performs comparably to dye chromoendoscopy in detecting lesions, though no randomised data exist for dysplasia detection in IBD surveillance. We therefore propose a randomised paired study comparing TXI with high-definition white-light endoscopy for dysplasia detection in IBD surveillance.

Eligibility

Min Age: 16 Years

Inclusion Criteria3

Patients >16 with inflammatory bowel disease undergoing surveillance colonoscopy.
Patients with Crohn's (L2/L3 Montreal classification) with >50% colonic involvement OR
Patients with ulcerative colitis with Extensive or left sided disease (E3 or E2 Montreal classification) for at least 8 years or a diagnosis of Primary sclerosing cholangitis concomitant with IBD.

Exclusion Criteria9

Disease duration <8 years unless a diagnosis of PSC
Incomplete colonoscopy
BBPS <6 or <2 in any segment
MES ≥2 or any variable of the SES-CD is ≥2 or any stenosis for >10cm segment (above the rectum)
Previous colorectal resection
Thrombocytopaenia (platelet count <50) or Coagulopathy precluding biopsy
Anticoagulation that has not been held appropriately prior to the procedure (must be held at least the morning of the procedure).
Pregnancy
Unable or unwilling to consent to study participation

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Interventions

DIAGNOSTIC_TESTTXI

Participants allocated to the "TXI" group undergo withdrawal using Texture and Colour Enhancement Imaging, while those in the "white light" group receive withdrawal with with high-definition white light endoscopy. Both procedures follow standardized protocols outlined in the study design.