RecruitingNot ApplicableNCT07273617

Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score

Sponsor

University Hospital, Basel, Switzerland

Enrollment

40 participants

Start Date

Sep 25, 2025

Study Type

INTERVENTIONAL

Conditions

Venous Hemodynamics

Summary

The hemodynamic effects of proning and PEEP may vary depending on pre- existing cardiac function, lung mechanics, and volume status, and the available evidence remains conflicting. The impact on the VExUS score of these manoeuvres is unclear. This study aims to assess the effects of PEEP in supine and prone position on the VExUS score as well as echocardiographic parameters in a cohort of healthy volunteers.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

Voluntary participants ≥ 18 years in good overall health with no relevant organ dysfunction in their medical history and signed informed consent form.

Exclusion Criteria6

Non-French or non-German speakers
Unable to provide informed consent
Body mass index > 40kg/m
Self-reported pregnancy
History of pneumothorax
Previously participated in the study

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Interventions

DIAGNOSTIC_TESTapplication of PEEP: starting PEEP = 15 mbar

The application of PEEP will be delivered by a intensive care respirator with dedicated NIV- mode (Hamilton C1, Hamilton Medical AG, Bonaduz Switzerland) via mask (VariFit, Sleepnet Corporation, New Hampshire, USA) available in four sizes (S, M, L, XL). Pressure support will be set at 5 mbar, and trigger will be adjusted according to participants' comfort. Fraction of inspired oxygen will be 0.21. If starting PEEP = 15 mbar: 5 min stepwise increase of PEEP Measurements with decremental PEEP (15, 10, 5, 0 mbar)

DIAGNOSTIC_TESTapplication of PEEP: starting PEEP = 0 mbar

The application of PEEP will be delivered by a intensive care respirator with dedicated NIV- mode (Hamilton C1, Hamilton Medical AG, Bonaduz Switzerland) via mask (VariFit, Sleepnet Corporation, New Hampshire, USA) available in four sizes (S, M, L, XL). Pressure support will be set at 5 mbar, and trigger will be adjusted according to participants' comfort. Fraction of inspired oxygen will be 0.21. If starting PEEP = 0 mbar: Measurement with increasing PEEP (0, 5, 10, 15 mbar)

Locations(1)

University Hospital Basel, Intensive Care Unit

Basel, Switzerland

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NCT07273617