RecruitingNCT07274631

A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine

Sponsor

CHU de Reims

Enrollment

470 participants

Start Date

Sep 15, 2025

Study Type

OBSERVATIONAL

Conditions

Asthma Chronic Obstructive Pulmonary Disease Cystic Fibrosis Bronchiectasis Primary Ciliary Dyskinesia

Summary

Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are characterised by lung inflammation and remodelling. Clinical, functional, microbiological, biological, pathological and prognostic features are highly variable and heterogeneous. Several phenotypes have been described within the same pathology, as similar phenotypic traits between different pathologies, or the coexistence of components of several diagnoses in the same patient, suggesting shared underlying mechanisms that could represent new therapeutic targets, beyond the initial medical diagnosis. The objectives of this prospective study are to analyze the phenotypic characteristics (clinical, demographic, biological, morphological, pathological, and microbiological characteristics) together with respiratory exposures and underlying mechanisms involving airway epithelium and inflammation processes in a cohort of patients diagnosed with asthma, COPD, bronchiectasis, CF, PCD and ILD.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is building a large research registry of patients with chronic inflammatory lung conditions — including asthma, COPD, bronchiectasis, cystic fibrosis, primary ciliary dyskinesia, and interstitial lung diseases — to better understand these conditions and develop personalized treatment approaches. Healthy volunteers are also included as a comparison group. **You may be eligible if...** - You are 18 or older - You are being followed for one of the listed lung conditions: asthma, COPD, bronchiectasis, cystic fibrosis, primary ciliary dyskinesia, or interstitial lung disease - Or you are a healthy volunteer willing to serve as a comparison participant - You are able to give informed consent **You may NOT be eligible if...** - You are protected by law due to legal incapacity or guardianship - You have a condition that prevents meaningful consent or participation - You do not have one of the specified lung conditions (unless enrolling as a healthy control) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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