RecruitingNot ApplicableNCT07276490

Central Haemodynamics and Pacing for AV Block

The Pacing in Atrioventricular Block: a Comparative Evaluation of Central Haemodynamics, Cardiac Function, and Quality of Life


Sponsor

University of Tartu

Enrollment

124 participants

Start Date

Nov 28, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Conduction system pacing and a medical device called Right ventricular pacing for people with atrioventricular block, conduction system pacing, and other related conditions. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICERight ventricular pacing

Pacemaker implantation with RV lead placement

DEVICEConduction system pacing

Pacemaker implantation with conduction system (LBBAP) lead placement


Locations(2)

North Estonia Medical Centre

Tallinn, Harju, Estonia

Tartu University Hospital

Tartu, Tartu, Estonia

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NCT07276490


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