Central Haemodynamics and Pacing for AV Block
The Pacing in Atrioventricular Block: a Comparative Evaluation of Central Haemodynamics, Cardiac Function, and Quality of Life
University of Tartu
124 participants
Nov 28, 2025
INTERVENTIONAL
Conditions
Summary
A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Pacemaker implantation with RV lead placement
Pacemaker implantation with conduction system (LBBAP) lead placement
Locations(2)
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NCT07276490