RecruitingNot ApplicableNCT07277309

Promoting Recovery After Brain Injury Using Focused Ultrasound

Sponsor

Massachusetts General Hospital

Enrollment

36 participants

Start Date

May 26, 2026

Study Type

INTERVENTIONAL

Conditions

Consciousness Disorders Disorders of Consciousness Due to Severe Brain Injury

Summary

The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.

Eligibility

Min Age: 18 YearsMax Age: 79 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Low-intensity focused ultrasound for people with consciousness disorders and disorders of consciousness due to severe brain injury. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years to 79 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICELow-intensity focused ultrasound

Low-intensity focused ultrasound pulsations (LIFUP) will be delivered to the brain, along with advanced MRI and EEG. Surrogate decision makers (family members) and recovered patients will undergo a semi-structured interview.