RecruitingPhase 1Phase 2NCT07278479

Study of [212Pb]Pb-DOTAM-MAM279 ([212Pb]Pb-MP0712) in Patients With Small Cell Lung Cancer and Other DLL3 Expressing Solid Tumors

A Phase 1/2a Study to Assess Safety, Tolerability, and Efficacy of [212Pb]Pb-DOTAM-MAM279 in Patients With Small Cell Lung Cancer and Other DLL3 Expressing Solid Tumors


Sponsor

Molecular Partners AG

Enrollment

138 participants

Start Date

Apr 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to evaluate the safety, tolerability, dosimetry and preliminary efficacy of \[212Pb\]Pb-MP0712, in patients aged ≥18 years with Small Cell Lung Cancer and other locally advanced or metastatic DLL3 positive tumors.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a new radioactive drug called [212Pb]Pb-MP0712 for people with small cell lung cancer or other hard-to-treat neuroendocrine cancers that have a protein called DLL3 on their cancer cells. **You may be eligible if...** - You are 18 or older - You have confirmed small cell lung cancer or another neuroendocrine cancer (such as certain stomach, cervical, bladder, or other cancers) that has progressed after prior treatment - Your cancer tests positive for DLL3 (a protein target for this drug) - You have at least one measurable tumor on scan - Your blood counts, kidney, and liver function are within acceptable ranges - Brain metastases are allowed if they are clinically stable **You may NOT be eligible if...** - You have an uncontrolled ongoing illness - You have significant side effects from prior treatment that haven't resolved - You have active serious heart disease - You have interstitial lung disease or pneumonitis - You have had another cancer in the past 2 years (some exceptions apply) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG[212Pb]Pb-MP0712

Radioligand Therapy

OTHER[203Pb]Pb-MP0712

Radioligand Imaging Agent


Locations(3)

United Theranostics

Glen Burnie, Maryland, United States

Nebraska Cancer Specialists

Omaha, Nebraska, United States

United Theranostics

Princeton, New Jersey, United States

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NCT07278479


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