RecruitingNCT07279402

TRIMPACT: Real-World First-Line Atezolizumab Use in Stage IV NSCLC With PD-L1 ≥50%

TRIMPACT: A Prospective Real-World Study of Atezolizumab Monotherapy as First-Line (Stage IV) Treatment in Patients With Non-Small Cell Lung Cancer With PD-L1 Tumor Cell Expression ≥50% and No Targetable Mutations


Sponsor

Antalya Training and Research Hospital

Enrollment

150 participants

Start Date

Sep 15, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This prospective, multicenter, real-world observational study aims to evaluate the clinical outcomes of first-line atezolizumab monotherapy in patients with stage IV non-small cell lung cancer (NSCLC) with PD-L1 tumor cell expression ≥50% and no targetable mutations. The study aim to determine how atezolizumab performs in routine clinical practice with respect to survival, treatment response, and safety outcomes in this patient population in Türkiye.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This observational study (TRIMPACT) is tracking real-world outcomes for patients in Turkey with advanced (Stage IV) non-small cell lung cancer with high PD-L1 expression who are receiving atezolizumab (an immunotherapy drug) as their first treatment. **You may be eligible if...** - You have been diagnosed with Stage IV non-small cell lung cancer - You are 18 or older - You have been prescribed atezolizumab as first-line treatment per standard clinical guidelines in Turkey - You have received up to 3 cycles of atezolizumab at the time of entering the study **You may NOT be eligible if...** - You are receiving atezolizumab for a reason other than lung cancer, or outside its approved indication - You are known to be hypersensitive (allergic) to atezolizumab - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(25)

Adana City Hospital

Adana, Turkey (Türkiye)

Afyonkarahisar Health Sciences University Hospital

Afyonkarahisar, Turkey (Türkiye)

Ankara Oncology Training and Research Hospital

Ankara, Turkey (Türkiye)

Memorial Ankara Hospital

Ankara, Turkey (Türkiye)

Ankara Bilkent City Hospital

Ankara, Turkey (Türkiye)

Ankara Atatürk Sanatoryum Training and Research Hospital

Ankara, Turkey (Türkiye)

Antalya Training and Research Hospital

Antalya, Turkey (Türkiye)

Antalya City Hospital

Antalya, Turkey (Türkiye)

Adnan Menderes University Faculty of Medicine Hospital

Aydin, Turkey (Türkiye)

Dicle University Hospital

Diyarbakır, Turkey (Türkiye)

Trakya University Faculty of Medicine Hospital

Edirne, Turkey (Türkiye)

Gaziantep City Hospital

Gaziantep, Turkey (Türkiye)

Bahçelievler Memorial Hospital

Istanbul, Turkey (Türkiye)

İstanbul Medipol Mega Hospital

Istanbul, Turkey (Türkiye)

Ümraniye Training and Research Hospital

Istanbul, Turkey (Türkiye)

Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi

Istanbul, Turkey (Türkiye)

Başakşehir Çam and Sakura City Hospital

Istanbul, Turkey (Türkiye)

Dokuz Eylul University Faculty of Medicine Hospital

Izmir, Turkey (Türkiye)

Ege University Hospital

Izmir, Turkey (Türkiye)

Necmettin Erbakan University Meram Faculty of Medicine Hospital

Konya, Turkey (Türkiye)

Mersin University Faculty of Medicine Hospital

Mersin, Turkey (Türkiye)

Ordu State Hospital

Ordu, Turkey (Türkiye)

Sakarya University Faculty of Medicine Hospital

Sakarya, Turkey (Türkiye)

Medical Park Samsun Hospital

Samsun, Turkey (Türkiye)

Karadeniz Technical University Farabi Hospital

Trabzon, Turkey (Türkiye)

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NCT07279402


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