RecruitingNCT07280091

Study of Skin and Gut Microbiome in a Skin Condition Involving Skin Barrier Impairment and Allergic Symptoms: Netherton Syndrome

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

30 participants

Start Date

May 26, 2026

Study Type

OBSERVATIONAL

Conditions

Netherton Syndrome

Summary

It is proposed to conduct an exploratory study to analyze the skin, intestinal, and salivary microbiome, as well as the skin mycobiome and virome, of patients (adolescents and young adults) with Netherton syndrome, a condition characterized by an impaired skin barrier that most likely promotes the development of allergic manifestations. The study will be conducted on patients with Netherton syndrome and control subjects in order to investigate possible correlation factors between the three microbiomes and identify which ones.

Eligibility

Min Age: 10 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called Blood samples, a biological treatment called Blood samples, and others for people with netherton syndrome. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALSuperficial skin swabs

Sampling areas: (18 swabs in total + 6 swabs for routine skin mapping) 1. Lesion area outside skin folds (e.g., back or limb) 2. Healthy area outside skin folds (e.g., back or limb) 3. Perioral area of the face 4. Scalp 5. Inguinal fold 6. Axillary fold

BIOLOGICALSuperficial skin swabs

Three superficial skin swabs: same locations as for Netherton patients

BIOLOGICALStool samples

A stool sample collected for analysis of the fecal microbiome and mycobiome.

BIOLOGICALSaliva samples

A saliva sample collected for analysis of the saliva microbiome and mycobiome.

BIOLOGICALBlood samples

For group A: cytokine profile from an additional blood sample taken during a blood draw for treatment For group B: cytokine profile if there is any residual blood sample from the treatment

BIOLOGICALBlood samples

For group A: cytokine profile from an additional blood sample taken during a blood draw for treatment For group B: cytokine profile if there is any residual blood sample from the treatment

OTHERData-Collection

Socio-demographic data and lifestyle habits of the patient and parents

OTHERData-Collection

Clinical data, treatment data, and results of biological tests carried out as part of routine monitoring