RecruitingPhase 4NCT07280260

Clinical Performance of Nobel N1 System

Effects of Early Loading Protocol on the Survival of the Nobel N1 Implant System: A Pilot Randomized Controlled Trial

Sponsor

Louisiana State University Health Sciences Center in New Orleans

Enrollment

50 participants

Start Date

Dec 15, 2025

Study Type

INTERVENTIONAL

Conditions

Tooth-loss Dental Implant

Summary

The purpose of the study is to evaluate whether N1 dental implants are successful when a final crown is placed on them at 6 weeks from implant placement surgery.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Males and females, age 18 or older
Can provide an Informed Consent in English.
Absence of a single posterior tooth in mandible or maxilla with presence of natural neighboring teeth (except for second molar which only requires presence of first molar)
Presence of antagonist teeth
Possibility and will for an immediate restoration.
Systemic health recorded as an American Society of Anesthesiologists (ASA) I or II

Exclusion Criteria12

· Unavailability to attend the follow-up visits.
A systemic contraindication for oral surgical procedures; ASA III or IV.
Pregnancy or nursing on screening or before the surgical procedure.
Diseases that could alter healing or bone metabolism (uncontrolled diabetes, diagnostic osteoporosis, etc.),
Taking medications that are altering healing or bone metabolism (bisphosphonates, long-time corticosteroids intake, RANK inhibitors, etc.)
Alcohol or drug abuse.
Current heavy smoking behavior (≥10 cigarettes/day).
Radiation therapy to the head or neck region.
Pathology in the implant planned sites that prevent implant placement.
Current diagnosis of Diabetes, which is uncontrolled (>7 HbA1C).
Need for sinus lift or vertical bone augmentation
Previously failed implant site