RecruitingPhase 1NCT07280494

To Observe the CD7-targeted CAR-T Therapy in the Treatment of MRD Positive T-ALL/LBL Post Allo-HSCT

An Open-label, Clinical Study of CD7-targeted CAR-T Cells for the Treatment of Measurable Residual Disease of T-lymphoblastic Leukaemia/Lymphoma Post Allogeneic Stem Cell Transplantation


Sponsor

Peking University People's Hospital

Enrollment

18 participants

Start Date

Aug 18, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

To observe the efficacy and safety of CD7-targeted chimeric antigen receptor T cells in the treatment of T-lymphoblastic leukaemia/lymphoma with postive measurable residual disease positive post allogeneic stem cell transplantation


Eligibility

Min Age: 3 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a CAR-T cell therapy targeting a protein called CD7 in patients with T-cell leukemia or lymphoma who have had a stem cell transplant but whose cancer is still detectable at a very low level (called minimal residual disease, or MRD-positive). **You may be eligible if...** - You are 3 years old or older - You have T-cell leukemia or lymphoma (T-ALL or LBL) that has relapsed or is not responding to treatment after a stem cell transplant - Your bone marrow shows less than 5% abnormal cells, but leukemia is still detected by sensitive flow cytometry testing - Your cancer cells test positive for a protein called CD7 - Your organ function (liver, kidneys) meets required levels **You may NOT be eligible if...** - You have a history of epilepsy, stroke, paralysis, dementia, or other significant brain/nerve conditions - You have an uncontrolled active infection - You have active hepatitis B, hepatitis C, HIV, or active CMV infection - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGCAR-T Therapy

autologous or donor-derived CD7-targeted CAR-T cells, single injection


Locations(1)

Peking University People's Hospital

Beijing, China, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07280494