Regenarative Treatment of Periocular Wrinkles With PDRN
Treatment of Periocular Wrinkles With the Active Ingredients PDRN, Hyaluronic Acid and Niacinamide, Applied by Needling or Microneedling: Randomized Clinical Trial"
University of Taubate
25 participants
Nov 30, 2025
INTERVENTIONAL
Conditions
Summary
This randomized clinical trial aims to compare two application techniques-needling (intradermal needling) and microneedling-for the delivery of an active-ingredient formulation containing 0.2% polynucleotides (PDRN), 2% hyaluronic acid, and 0.1% niacinamide for the treatment of periocular wrinkles related to aging.
Eligibility
Inclusion Criteria2
- Glogau II and III
- Fitzpatrick II and III
Exclusion Criteria4
- Pregnancy
- immune diseases
- tabagism
- aesthetics facial treatment in the past 6 months
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Interventions
three periorbital intradermal injection sessions, at 30-day intervals, of polydeoxyribonucleotides (PDRN) 0.5% combined with 2% hyaluronic acid and 0.1% niacinamide
three periorbital micro needling sessions, at 30-day intervals, with polydeoxyribonucleotides (PDRN) 0.5% combined with 2% hyaluronic acid and 0.1% niacinamide
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07280637