RecruitingNCT07281196

Semaglutide Effects on Sleep Apnea in Patients With Type 2 Diabetes/Obesity and Comorbid Obstructive Sleep Apnea

A Real-World Study on Changes in Sleep Apnea Among Patients With Type 2 Diabetes/Obesity and Comorbid OSA After Short-Term Treatment With Semaglutide


Sponsor

Shanghai Fengxian District Central Hospital

Enrollment

15 participants

Start Date

Jan 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Semaglutide (a GLP-1RA) is approved for type 2 diabetes mellitus T2DM and obesity, but its effect on obstructive sleep apnea OSA remains unclear. To evaluate changes in Apnea-Hypopnea Index (AHI) after 1-week and 4-week semaglutide treatment in T2DM/obesity patients with OSA, we conducted a single-center real-world study (RWS) of 15 patients. Outcomes assessed included AHI, weight, BMI, blood pressure, blood glucose(fasting blood glucose, glycated albumin),liver function, blood lipids, waist circumference, and other metabolic parameters, to provide real-world evidence for semaglutide in OSA management.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether semaglutide, a medication used for weight loss and diabetes, can also improve sleep apnea in people who have both type 2 diabetes or obesity and obstructive sleep apnea (a condition where breathing repeatedly stops during sleep). **You may be eligible if...** - You are 18 to 65 years old - Your BMI is 27 or higher, and you have at least one of: high blood pressure, high cholesterol, cardiovascular disease, or type 2 diabetes - Diet and exercise alone have not been enough to manage your condition - You have been diagnosed with obstructive sleep apnea - You have complete medical records available **You may NOT be eligible if...** - Your weight gain is caused by a hormonal disorder (like Cushing's syndrome or an underactive thyroid) - You have severe kidney or liver problems - You received hormonal drugs, antibiotics, or weight-loss surgery in the past month Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSemaglutide Subcutaneous Injection

This study is a observational study and the treatments are based on the clinical practice. In the study, patients with treatments were recorded. According to the instructions of drugs, 1ml of the injection contains 1.34mg of semaglutide. Each pre-filled injection pen contains 2mg of semaglutide and is placed in 1.5ml of solution. This product should be injected once a week.


Locations(1)

Shanghai Fengxian District Central Hospital

Shanghai, China

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NCT07281196


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