IOP Reduction in Pigmentary Glaucoma Using DSLT
Direct Selective Laser Trabeculoplasty Providing Effective Intraocular Pressure Reduction in Pigmentary Glaucoma Patients
Mann Eye Institute
45 participants
Mar 19, 2026
OBSERVATIONAL
Conditions
Summary
This study is a single-site, single-arm, prospective, observational study of IOP reduction after DSLT. Subjects will be assessed up to 12 months post-operatively. Clinical evaluations will include IOP and number of glaucoma medications.
Eligibility
Inclusion Criteria4
- Adult patients with pigmentary dispersion syndrome with elevated IOP or mild to moderate (based on AAO Preferred Practice Program criteria) pigmentary glaucoma with glaucomatous optic neuropathy and corresponding visual field/RNFL loss.
- Treatment naive, or washed out IOP ranging from ≥18-34 mmHg
- Central corneal thickness (CCT) 480-600 µm
- Able to complete medication washout and follow-up
Exclusion Criteria7
- Prior incisional glaucoma surgery or glaucoma-related procedures in the study eye
- Prior laser trabeculoplasty <3 years
- Prior intraocular surgery and refractive surgery, except for cataract surgery unless greater than 2 years
- Patients anticipating cataract surgery within the follow-up period
- History of ocular inflammation and infection
- All other secondary glaucoma including exfoliative
- Patients unable to have DSLT treatment
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Interventions
DSLT is an innovative adaptation of traditional SLT. Rather than using a gonioscopic lens, DSLT applies laser energy directly through the limbus to the trabecular meshwork in a few seconds.
Locations(1)
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NCT07281391