Ablation With the PFA System With a Large-Area Focal Catheter for the Treatment of Persistent Atrial Fibrillation

This study is testing a new catheter ablation technique (using electrical pulses rather than heat to destroy abnormal heart tissue) for treating persistent or paroxysmal atrial fibrillation — a condition where the heart beats irregularly. **You may be eligible if...** - You have been diagnosed with paroxysmal atrial fibrillation (episodes that start and stop on their own, lasting less than 7 days) or persistent atrial fibrillation (lasting longer) - Your irregular heartbeat has been documented on an ECG, Holter monitor, or similar device within the past 12 months - A doctor has confirmed your symptoms are caused by atrial fibrillation **You may NOT be eligible if...** - You have certain types of structural heart disease (e.g., severe valve problems or dilated cardiomyopathy) - You have had a previous catheter ablation for any heart rhythm problem - You have other heart rhythm problems that also require ablation at the same time - You have uncontrolled high blood pressure or other conditions that may make ablation unsafe Talk to your doctor to see if this trial is right for you.