RecruitingPhase 2NCT07284758

A Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma

A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Subjects With Relapsed/Refractory Multiple Myeloma


Sponsor

C4 Therapeutics, Inc.

Enrollment

100 participants

Start Date

Feb 18, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This is a Phase 2, open-label, single-arm, multicenter study to assess the antimyeloma activity and further characterize the safety, tolerability, PK, and PD of cemsidomide in combination with dexamethasone in participants with relapsed/refractory multiple myeloma (r/r MM).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a new drug called cemsidomide combined with a steroid (dexamethasone) in people with multiple myeloma — a cancer of blood plasma cells — that has come back or stopped responding to previous treatments. **You may be eligible if...** - You are 18 or older with a confirmed diagnosis of multiple myeloma - Your myeloma has come back or stopped responding to treatment - You have already tried at least 3 different treatment regimens, including an immunomodulatory drug, a proteasome inhibitor, an anti-CD38 antibody, and a T-cell engager or CAR-T cell therapy - Your organs (liver, kidneys, heart) are functioning adequately - Side effects from previous treatments have mostly cleared up **You may NOT be eligible if...** - You have not yet tried the required previous treatments - You are pregnant or planning to become pregnant - Your organ function does not meet the study requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCemsidomide

dosed orally (PO) once a day (QD) 14 days on/14 days off for each 28-day cycle

DRUGDexamethasone

dosed PO once a week (QW) on Days 1, 8, 15, and 22 for each 28-day cycle


Locations(3)

Berenson Cancer Center

West Hollywood, California, United States

START Midwest

Grand Rapids, Michigan, United States

START San Antonio

San Antonio, Texas, United States

View Full Details on ClinicalTrials.gov

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NCT07284758


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