Effect of Misoprostol on Fluid Deficit Volume in Hysteroscopic Myomectomy

This trial is studying whether a medication called misoprostol, given rectally before a hysteroscopic myomectomy (a procedure to remove uterine fibroids through the vagina), can reduce fluid absorption during the surgery — which is a safety concern. **You may be eligible if...** - You are between 18 and 50 years old - You have uterine fibroids between 1–3 cm in size, confirmed by ultrasound or MRI in the last 12 months - You are scheduled for a hysteroscopic myomectomy using a Myosure or resectoscope device - You are willing to receive either misoprostol or a placebo rectally before the procedure - You have a negative pregnancy test before surgery **You may NOT be eligible if...** - You are pregnant or have gone through menopause - You have a history of gynecologic cancer - You have a known allergy or intolerance to misoprostol - You are outside the 18–50 age range Talk to your doctor to see if this trial is right for you.