A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer
A Phase II, Randomized, Multicenter, Open-Label Study Evaluating the Efficacy and Safety of the Combination of Inavolisib Plus Enzalutamide Versus Physician's Choice of ARPI or Docetaxel in Patients With Metastatic Castration-Resistant Prostate Cancer
Hoffmann-La Roche
100 participants
Mar 11, 2026
INTERVENTIONAL
Summary
This study will evaluate the efficacy and safety of the combination of inavolisib plus enzalutamide compared with physician's choice of alternative androgen receptor pathway inhibitor (ARPi) or docetaxel in biomarker-selected participants with metastatic castrate-resistant prostate cancer (mCRPC) who have received one prior second-generation ARPi.
Eligibility
Plain Language Summary
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Interventions
Inavolisib will be administered orally as per the schedule specified in the protocol.
Enzalutamide will be administered orally as per the schedule specified in the protocol.
Abiraterone will be administered orally as per the schedule specified in the protocol.
Docetaxel will be administered intravenously as per the schedule specified in the protocol.
Locations(13)
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NCT07287150