Exploring the Effects of Exercise Combined With BFRT on Healthy and Patients With CKD
The Feasibility and Effects of Exercise Training Combined With Blood Flow Restriction Training on Exercise Capacity and Exercise Tolerance in Patients With Chronic Kidney Disease
National Cheng Kung University
120 participants
Oct 4, 2025
INTERVENTIONAL
Conditions
Summary
Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in healthy and CKD patients
Eligibility
Inclusion Criteria6
- Healthy
- • Aged 20\~85 years old
- Aged 20\~85 years old
- eGFR\< 90 ml/min/1.73 m2 over 3 months
- Stable condition without worsening in the past 3 months
- Ability to understand and follow verbal commends and cooperate with an exercise training program
Exclusion Criteria20
- Severe uncontrolled metabolic diseases (e.g., hyperthyroidism, diabetes, hypertension, hyperlipidemia, etc.)
- Severe pulmonary or cardiovascular diseases (e.g., pulmonary hypertension, chronic obstructive pulmonary disease (COPD), heart failure, cardiac arrhythmia)
- Presence of a cardiac pacemaker or a history of myocardial infarction within the past six months
- Severe musculoskeletal or neuromuscular disorders (e.g., advanced arthritis, limb amputation, post-polio syndrome, Parkinson's disease)
- Unstable vital signs (e.g., systolic blood pressure ≥180 mmHg, diastolic blood pressure ≥90 mmHg, requiring vasopressors, or resting heart rate \>100 bpm)
- Prone to bruising
- Recent inflection \< 1 month
- Pregnancy
- Kidney function impairment
- Cancer
- Simultaneously participating in other research
- CKD
- Severe uncontrolled metabolic diseases (e.g., hyperthyroidism, diabetes, hypertension, hyperlipidemia, etc.)
- Severe pulmonary or cardiovascular diseases (e.g., pulmonary hypertension, chronic obstructive pulmonary disease (COPD), heart failure, cardiac arrhythmia)
- Presence of a cardiac pacemaker or a history of myocardial infarction within the past six months
- Severe musculoskeletal or neuromuscular disorders (e.g., advanced arthritis, limb amputation, post-polio syndrome, Parkinson's disease)
- Unstable vital signs (e.g., systolic blood pressure ≥180 mmHg, diastolic blood pressure ≥90 mmHg, requiring vasopressors, or resting heart rate \>100 bpm)
- Abnormal blood biochemical parameters (e.g., white blood cell count \<2500/mm³, hemoglobin \<8 mg/dL, total bilirubin \>3 mg/dL, liver enzymes (GOT/AST, GPT/ALT) \>3 times the upper limit of normal, platelet count \<75,000/mm³
- Sensory or motor dysfunctions that affect walking ability
- Diagnosed systemic diseases under ongoing treatment (e.g., systemic lupus erythematosus, cancer, malignancies).
Interventions
The aerobic exercise intervention will utilize stationary bike. The program will be conducted 2 times per week over a 12 weeks
Blood flow restriction intervention will combined aerobic exercise and resistance exercise. The program will be conducted 2 times per week over a 12 weeks
The resistance exercise will bilateral leg extension. The program will be conducted 2 times per week over a 12 weeks
The participants will received self-care technique and home-based exercise approach
Locations(1)
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NCT07288905