RecruitingPhase 2NCT07289763
Phase II Randomized, Open-label, Multicenter Clinical Study Evaluating the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of SHR-2173 Injection in Patients With Primary Membranous Nephropathy
Sponsor
Guangdong Hengrui Pharmaceutical Co., Ltd
Enrollment
75 participants
Start Date
Dec 31, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
To investigate the safety, efficacy, pharmacokinetics, and pharmacodynamics of SHR-2173 injection in patients with primary membranous nephropathy
Eligibility
Min Age: 18 YearsMax Age: 75 Years
Inclusion Criteria3
- Age 18-75 years, regardless of gender;
- Weight ≥40.0 kg at screening;
- Diagnosed as primary membranous nephropathy through kidney biopsy.
Exclusion Criteria5
- Secondary membranous nephropathy.
- Subjects developed rapidly progressive glomerulonephritis or required kidney transplantation.
- Subjects who have undergone kidney dialysis in the previous 12 months or are expected to require dialysis during the study period.
- Subjects who have a malignant tumor or a history of malignant tumor
- Subjects who have undergone major surgery within the previous 3 months, or plan to undergo major surgery during the study period.
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Interventions
DRUGSHR-2173 injection
SHR-2173 injection, with a total of 8 administrations
DRUGSHR-2173 injection
SHR-2173 injection, with a total of 16 administrations
DRUGSHR-2173 injection
SHR-2173 injection , with a total of 32 administrations
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07289763
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