RecruitingNot ApplicableNCT07290842

The Effects of Dietary Nitrate in Patients With Hypertensive Kidney Injury


Sponsor

Gødstrup Hospital

Enrollment

20 participants

Start Date

Dec 8, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The study aims to study the effects of diatery nitrate in patients with hypertension and hypertensive kidney injury. The study is a randomized, placebo-controlled, double-blinded crossover trial. 14-20 patients with hypertension and CKD I-III will be randomized to receive either nitrate or placebo delivered in the form of beetroot juice. Effect variables will be measured before and after a 2 week treatment. After a washout period of 14 days, the subjects are crossed over to the opposite treatment. The study is terminated by measuring effect variables after the second treatment period.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether drinking nitrate-rich beetroot juice or supplements can lower blood pressure and protect kidney function in people who have high blood pressure that has already caused mild kidney damage. **You may be eligible if...** - You have high blood pressure, either newly diagnosed or controlled on up to 2 medications - You have mild-to-moderate chronic kidney disease (stages 1–3) caused by high blood pressure - Your kidney protein leakage (albumin/creatinine ratio) is below 500 mg/g - Your kidney filtration rate (eGFR) is above 30 - Your BMI is 35 or below - You are willing to follow dietary guidance during the study **You may NOT be eligible if...** - Your blood pressure is very high or poorly controlled - You have more advanced kidney disease - You have other major kidney, heart, or health conditions that could interfere Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTBeetroot Juice - Active

Intervention is beetroot juice ("Beet It concentrated beetroot juice shots", James White Drinks Ltd, Ipswich, England) The nitrate content of the juice is standardized. The dose of nitrate will be 70 ml/day corresponding to intake of 6.5 mmol/400 mg of nitrate.

DIETARY_SUPPLEMENTBeetroot juice placebo

The placebo beetroot juice is a corresponding nitrate free beetroot juice, obtained from the manufacturer ("Beet It nitrate depleted shots", James White Drinks Ltd, Ipswich, England.). The placebo juice appears identical to the nitrate containing juice regarding color and taste.


Locations(1)

University Clinic in Nephrology and Hypertension, Gødstrup Regional Hospital and Aarhus University

Herning, Denmark

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NCT07290842


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