To Conduct Multi-omics Integrated Studies in Peripheral Blood, Such as Fragment Omics, Metabolomics and Epigenetics, and Establish Non-invasive Dynamic Follow-up Monitoring Programs During Perioperative and Postoperative Periods (Observational Study)

This study collects blood and tissue samples from lung cancer patients at multiple time points to study whether genetic and molecular signals in the blood (liquid biopsy) can predict whether the cancer will come back after surgery and immunotherapy-based treatment. **You may be eligible if...** - You are 18 to 84 years old - You have non-small cell lung cancer (NSCLC) at stage IB to IIIA - You have had surgery to remove the cancer (radical resection) - You completed standard pre-surgery treatment involving immunotherapy combined with platinum-based chemotherapy - Your tumor is not a pure ground-glass nodule on imaging **You may NOT be eligible if...** - Your post-surgery pathology showed something other than NSCLC - Your blood or tissue samples are insufficient or low quality - You have had another cancer within the past 5 years Talk to your doctor to see if this trial is right for you.