3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion
A Double-blind Placebo-controlled Randomized Controlled Trial (RCT) of 3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion
Women's College Hospital
110 participants
Apr 27, 2026
INTERVENTIONAL
Conditions
Summary
Intrauterine device (IUD) insertion is a common contraceptive procedure often associated with moderate to severe pain, particularly among nulliparous individuals. Current pain management strategies, such as over-the-counter analgesics, are frequently inadequate. Methoxyflurane, a short-acting, self-administered inhaled analgesic, has been shown to provide rapid and effective pain relief in acute and procedural settings. This study aims to evaluate whether 3 mL of inhaled Methoxyflurane (via Penthrox inhaler) improves patient satisfaction by reducing pain and anxiety during IUD insertion.
Eligibility
Plain Language Summary
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Interventions
3 mL of Methoxyflurane via a handheld inhaler
3 mL of Normal Saline via an identical placebo handheld inhaler
Locations(1)
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NCT07295054