RecruitingPhase 1Phase 2NCT07296341

HRS-4642 Combination With Other Antitumor Therapies in Patients With Solid Tumors

A Phase IB/II Study To Evaluate the Safety, Tolerability, and Preliminary Efficacy of HRS-4642 Combination With Other Antitumor Therapies in Patients With Solid Tumors


Sponsor

Shanghai Hengrui Pharmaceutical Co., Ltd.

Enrollment

60 participants

Start Date

Jan 8, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a randomized, open-label, multicenter Phase II clinical trial designed to evaluate the Safety, Tolerability and Preliminary Efficacy of HRS-4642 Combination with Other Antitumor Therapies in Patients with Solid Tumors


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests a drug called HRS-4642 in combination with other cancer-fighting therapies in patients with advanced solid tumors, particularly pancreatic cancer, that cannot be removed with surgery. **You may be eligible if...** - You are between 18 and 75 years old - You are in good physical condition (ECOG score 0 or 1) - You have advanced or metastatic pancreatic cancer that is not surgically removable - Your life expectancy is at least 12 weeks - Your organ function meets the required levels **You may NOT be eligible if...** - You have had recent major surgery - You have active brain metastases (cancer in the brain) - You have significant heart problems - You are pregnant or breastfeeding - You are currently enrolled in another clinical trial Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGHRS-4642;Adebrelimab Injection; nab-paclitaxel; gemcitabine

HRS-4642 combination with Adebrelimab Injection, nab-paclitaxel in combination with gemcitabine

DRUGHRS-4642;nab-paclitaxel; gemcitabine

nab-paclitaxel in combination with gemcitabine


Locations(1)

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

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NCT07296341