RecruitingNCT07297394
Mechanisms of Maternal Immune Tolerance in Early Pregnancy
Sponsor
University Hospital, Basel, Switzerland
Enrollment
100 participants
Start Date
Mar 2, 2026
Study Type
OBSERVATIONAL
Conditions
Summary
This study explores the mechanisms of maternal immune tolerance in early pregnancy by characterizing immune cell profiles and functional pathways during the first trimester. The goal is to identify immunological factors that support healthy gestation and prevent complications such as miscarriages.
Eligibility
Sex: FEMALEMin Age: 18 Years
Inclusion Criteria3
- Blood from patients will be included before and during pregnancies (or failed implantation) conceived through IVF/ICSI (Intracytoplasmic Sperm Injection) treatment and in case of miscarriage.
- where the patient (pregnant person) was ≥ 18 years of age.
- where the patient (pregnant person) signed a written informed consent.
Exclusion Criteria2
- Certain maternal infections (HIV, Hepatitis B, Hepatitis C, Syphilis)
- Patients under immunosuppressive medications (at time of blood sample collection)
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
OTHERBlood sampling
Blood samples will be analyzed before and during early pregnancy as well as after early miscarriage
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07297394
Related Trials
Intra-abdominal Pressure, Abdominal Circumference, and Spinal Block Level in Cesarean Section
NCT074063731 location
Different Medications to Induce Labor
NCT062590972 locations
Comparison of Bone Mineral Density in the Third Trimester Between Women in Singleton and Twin Pregnancies Using Questionnaires and REMS Densitometric Examination
NCT075085531 location
Vitamin D Dynamics in Women
NCT027052871 location
Study of Ceftriaxone and Benzathine Penicillin G During Pregnancy
NCT072078769 locations