RecruitingNCT07297394

Mechanisms of Maternal Immune Tolerance in Early Pregnancy

Sponsor

University Hospital, Basel, Switzerland

Enrollment

100 participants

Start Date

Mar 2, 2026

Study Type

OBSERVATIONAL

Conditions

Pregnancy In-Vitro Fertilization Immune Tolerance

Summary

This study explores the mechanisms of maternal immune tolerance in early pregnancy by characterizing immune cell profiles and functional pathways during the first trimester. The goal is to identify immunological factors that support healthy gestation and prevent complications such as miscarriages.

Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria3

Blood from patients will be included before and during pregnancies (or failed implantation) conceived through IVF/ICSI (Intracytoplasmic Sperm Injection) treatment and in case of miscarriage.
where the patient (pregnant person) was ≥ 18 years of age.
where the patient (pregnant person) signed a written informed consent.

Exclusion Criteria2

Certain maternal infections (HIV, Hepatitis B, Hepatitis C, Syphilis)
Patients under immunosuppressive medications (at time of blood sample collection)

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