RecruitingPhase 2Phase 3NCT07298642

Extended-field Proton Therapy for Cervical Cancer

Proton Therapy in Extended-field Irradiation for Cervical Cancer

Sponsor

National Taiwan University Hospital

Enrollment

44 participants

Start Date

Sep 30, 2025

Study Type

INTERVENTIONAL

Conditions

Cervical Cancer

Summary

Severe lymphopenia is a common complication of extended-field radiotherapy in cervical cancer, significantly impacting immune function and clinical outcomes. This study aims to evaluate whether proton therapy, with its superior dose distribution, can reduce lymphopenia and improve survival and toxicity profiles compared to photon therapy.

Eligibility

Sex: FEMALEMin Age: 20 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study tests extended-field proton therapy — a precise form of radiation therapy that targets a larger area including nearby lymph nodes — in patients with locally advanced cervical cancer (stage IIIC or higher). **You may be eligible if...** - You are between 20 and 85 years old - You have cervical cancer at stage IIIC or more advanced - You are in good physical condition (ECOG 0-1) - Your doctor has determined you are a candidate for extended-field radiation - You may receive concurrent chemotherapy or a short course of induction chemotherapy **You may NOT be eligible if...** - Your cancer is at an earlier stage (below IIIC) - You have serious medical conditions that make radiation unsafe - You have had prior pelvic radiation - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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