Prospective Observational Trial of Image-guided Ablative STereotactic bOdy Radiation Therapy for Primary kidNey Cancer: the STONE Trial

This study is testing a precise, non-surgical radiation treatment called stereotactic body radiation therapy (SBRT) for people with early-stage kidney cancer who cannot or do not want to have surgery. Researchers want to learn how well this targeted radiation approach works and how safe it is. **You may be eligible if...** - You are 18 or older - You have been diagnosed with kidney cancer (renal cell carcinoma) confirmed by a biopsy - Your tumor is in an early stage (cT1), is a single lesion, and is no larger than 7 cm - Your doctors consider surgery too risky, or you have decided not to have surgery - Your cancer has not spread to other parts of your body - Your kidneys are functioning reasonably well (eGFR of 30 or higher) **You may NOT be eligible if...** - Your kidneys are functioning poorly (eGFR below 30) - You have already had radiation therapy on the same area - You have previously received systemic (drug) treatment for kidney cancer - Your tumor is larger than 7 cm - Your cancer has spread to other parts of your body - Your life expectancy is less than 3 months Talk to your doctor to see if this trial is right for you.