RecruitingNCT07299539

Treatment of Enterococcus Faecalis Bacterem

Impact on Mortality of the Choice Between a Mono- Versus Combination Antibiotic Therapy in Enterococcus Faecalis Bacteremia


Sponsor

University Hospital, Strasbourg, France

Enrollment

700 participants

Start Date

Feb 24, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Enterococcus faecalis is a germ frequently responsible for bacteremia which can be severe with 15-25% risk of mortality and 26% risk of infectious endocarditis. There is no recommendation for the treatment of "simple" Enterococcus faecalis bacteremia (meaning without infectious endocarditis at diagnosis), nor studies comparing monotherapy versus combination antibiotic therapy. Our main objective is to study the impact on mortality of bacteriostatic monotherapy and bactericidal combination antibiotic therapy in patients with Enterococcus faecalis bacteremia. We aim to also study the mortality up to three months, the failures of treatment, the modalities of treatment, the renal toxicity and the bacterial resistance.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • Subject of legal age (≥18 years)
  • Having a positive blood culture result for Enterococcus faecalis identified within the microbiology laboratory of the University Hospital of Strasbourg during the period from 01 January 2017 to 31 December 2023.

Exclusion Criteria8

  • Penicillin treatment < 7 days
  • Treatment not containing a penicillin effective against enterococci among those studied: amoxicillin or piperacillin-tazobactam
  • Combination of penicillin with another antibiotic effective against enterococci other than cephalosporins or aminoglycosides (glycopeptides, linezolids, carbapenems, levofloxacin, moxifloxacin).
  • Bacteremia with one or more other pathogens within the first 7 days of bacteremia
  • Infective endocarditis at diagnosis and within the first 7 effective days of treatment
  • Resistance of Enterococcus faecalis to amoxicillin
  • Mortality <72 hours after initiation of antibiotic therapy
  • Lack of information regarding the chosen antibiotic treatment

Interested in this trial?

Get notified about updates and connect with the research team.


Locations(1)

Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France

Strasbourg, France

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07299539