RecruitingNot ApplicableNCT07300384

Acute Effects of Blood Flow Restriction Training to Failure on Hypoalgesia in Patients With Severe Knee Osteoarthritis Using Dynamic or Fixed Occlusion Pressure

Sponsor

University of Valencia

Enrollment

45 participants

Start Date

Feb 25, 2026

Study Type

INTERVENTIONAL

Conditions

Severe Knee Osteoarthritis

Summary

This study aims to compare the acute effects on hypoalgesia of training to failure using blood flow restriction (BFR) with dynamic occlusion versus BFR with fixed occlusion in patients with severe gonarthrosis. Two different training conditions will be performed with varying levels of blood flow occlusion (%BFR) and percentage of load (%RM): 1) 30% RM and 50% BFR with dynamic pressure; 2) 30% RM and 50% BFR with fixed pressure. Each participant will complete two individual sessions under different training conditions, randomly assigned with a 72-hour interval between sessions.

Eligibility

Min Age: 50 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Low-intensity resistance exercise to failure with moderate arterial occlusion pressure and dynamic pressure. and a medical device called Low-intensity resistance exercise to failure with moderate arterial occlusion pressure and fixed pressure. for people with severe knee osteoarthritis. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 50 Years to 85 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICELow-intensity resistance exercise to failure with moderate arterial occlusion pressure and dynamic pressure.

A single quadriceps extension exercise at 30% of 1 repetition maximum (1RM) with dynamic occlusion at 50% of limb occlusion pressure (LOP). The exercise protocol will consist of 4 sets to muscle failure with 30 seconds of rest between sets and a continuous level of occlusion.

DEVICELow-intensity resistance exercise to failure with moderate arterial occlusion pressure and fixed pressure.

A single quadriceps extension exercise at 30% of 1 repetition maximum (1RM) with fixed occlusion at 50% of limb occlusion pressure (LOP). The exercise protocol will consist of 4 sets to muscle failure with 30 seconds of rest between sets and a continuous level of occlusion.

Locations(2)

Faculty of Physiotherapy, University of Valencia

Valencia, Valencia, Spain

University of Valencia

Valencia, Valencia, Spain

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NCT07300384

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