RecruitingNot ApplicableNCT07300696

Functional MRI for Monitoring Progression and Assessing Trends in ILD

Functional Magnetic Resonance Imaging of the Lung to Detect Regional Reversibility and Progression in Interstitial Lung Disease

Sponsor

University Hospital Heidelberg

Enrollment

200 participants

Start Date

Nov 20, 2025

Study Type

INTERVENTIONAL

Conditions

Interstitial Lung Diseases (ILD)

Summary

The main objective of this study is to investigate the utility of functional MRI to differentiate, characterize, and monitor subgroups of ILD. This can be broken down into three specific objectives: Determine if ILD features observed on high-resolution computed tomography (HRCT), such as ground glass opacities (GGO), are functionally different. Analyse MRI metrics within each subgroup to determine whether these metrics distinguish different ILDs. Assess MRI metrics longitudinally to see if these parameters change with disease progression, stability, or reversibility.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Clinical indication for a routine HRCT because of either newly diagnosed idiopathic pulmonary fibrosis (IPF) or hypersensitivity pneumonitis (HP) or idiopathic non-specific interstitial pneumonia (iNSIP), suspected diagnosis, or follow-up
Capacity to consent
Ability to participate fully in the study (defined by the ability to lie still for the duration of imaging)

Exclusion Criteria4

Pregnancy and breast feeding
Persons under the age of 18 and persons not able to give informed consent
Any medical conditions that could hinder the ability to adhere to the protocol
Any MRI contraindication, including previous allergic reactions to Gd-based MRI contrast material and renal dysfunction (eGFR \< 30 ml min/1,73 m2)

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Interventions

DIAGNOSTIC_TESTLung MRI Protocol with Functional and Contrast-Enhanced Sequences

Participants will undergo a lung MRI protocol consisting of structural imaging, non-contrast functional imaging, and contrast-enhanced imaging. Some sequences are custom-developed and performed during free breathing to accommodate patients with respiratory limitations.