1726-nm Diode Laser for Lip Fordyce Spots
Efficacy and Safety of a 1726-nm Sebaceous-Targeting Diode Laser for the Treatment of Fordyce Spots of the Lips: A Prospective Pilot Study
Venus Research Center
20 participants
Nov 1, 2025
INTERVENTIONAL
Conditions
Summary
Fordyce spots are benign ectopic sebaceous glands commonly affecting the lips and vermilion border, often causing cosmetic concern. This prospective pilot study evaluates the efficacy and safety of a 1726-nm sebaceous-targeting diode laser (Accure®) for the cosmetic treatment of Fordyce spots of the lips. Participants will receive 2-3 laser sessions and will be followed for 6-12 months to assess clinical improvement, patient satisfaction, and safety outcomes.
Eligibility
Inclusion Criteria5
- Age ≥18 years
- Clinically evident Fordyce spots involving: Upper and/or lower lips and/or vermilion border
- Cosmetic concern related to Fordyce spots
- Willingness to comply with study procedures and follow-up visits
- Ability to provide written informed consent
Exclusion Criteria7
- Active herpes labialis at the treatment site
- History of frequent HSV reactivation without willingness for antiviral prophylaxis
- Isotretinoin use within the preceding 6 months
- Active inflammatory or infectious lip/mucosal disease (e.g., lichen planus, cheilitis, candidiasis)
- Known tendency for keloid or hypertrophic scarring Pregnancy or lactation
- Immunosuppression or uncontrolled systemic illness
- Previous treatment of Fordyce spots in the target area within 3 months
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Interventions
A 1726-nm sebaceous-targeting diode laser (Accure®) delivering multi-pulse, temperature-guided energy with continuous cooling, applied to the lips and vermilion border in 2-3 treatment sessions spaced four weeks apart.
Locations(1)
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NCT07300917