RecruitingNCT07301853

Longitudinal Follow-up and Health-Related Outcomes in Liver Transplant Recipients and Living Donors

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Enrollment

9,999 participants

Start Date

Nov 24, 2025

Study Type

OBSERVATIONAL

Conditions

Living Donor Liver Transplantation Recipients Deceased Donor Liver Transplantation Recipients Living Liver Donor

Summary

This prospective cohort study aims to identify risk factors for postoperative adverse events in liver transplant recipients and living donors. By collecting comprehensive clinical data and conducting systematic long-term follow-up, the researchers intend to establish a specialized, standardized, and individualized follow-up management system. The ultimate goal is to optimize intervention strategies and improve patient prognosis and quality of life for both recipients and donors.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Patients undergoing liver transplantation or living donor hepatectomy at the study center (living donor should be approved by the hospital ethics committee for living organ donation);
Age 18 years or older;
Willing to participate in the long-term follow-up management program;
Signed informed consent form;

Exclusion Criteria4

Patients undergoing combined organ transplantation
Patients with severe mental illness or cognitive impairment who are unable to cooperate with follow-up assessments.
Donors whose surgery is aborted intraoperatively for any reason.
Unable or unwilling to comply with the long-term follow-up schedule.

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Interventions

PROCEDUREliver transplantation

Patients undergo standard liver transplantation according to clinical protocols. Postoperative management and follow-up are conducted per routine standard of care. Clinical data, including survival, adverse events, and quality of life (assessed by questionnaires/scales), are collected observationally at regular follow-up intervals.

PROCEDURELiving Donor Hepatectomy

Living donors undergo standard hepatectomy procedures. Postoperative recovery and long-term health outcomes are monitored through routine follow-up visits and assessments.

Locations(1)

The Second Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

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NCT07301853