RecruitingPhase 2NCT07303894

A Study of Isoquercetin in People With Ovarian Cancer

Randomized, Multi-dose, Placebo-controlled Phase 2 Trial of Oral Isoquercetin to Reduce Thrombin Generation in Ovarian Cancer


Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

90 participants

Start Date

Jan 22, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to test whether isoquercetin can reduce markers in the blood that may indicate the risk of blood clots in people with ovarian cancer. The effects of isoquercetin will be compared with those of a placebo.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding isoquercetin — a naturally occurring plant compound with anti-clotting and possibly anti-cancer properties — to standard chemotherapy can improve outcomes for women with ovarian cancer receiving first-line (initial) treatment. Researchers are also looking at whether it reduces dangerous blood clots, which are a common complication of both cancer and chemotherapy. **You may be eligible if...** - You have confirmed ovarian cancer (epithelial, serous, or clear cell type) - You are currently starting your first round of chemotherapy (isoquercetin would begin during cycle 1 or 2) - You are 18 or older with a life expectancy of more than 6 months - You are in good enough health (ECOG performance status below 2) - Your blood counts and organ function meet the minimum requirements **You may NOT be eligible if...** - You have already completed or are on a later line of chemotherapy - You have a different type of ovarian cancer (e.g., germ cell tumor) - You have serious bleeding disorders or are on certain blood thinners - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGIsoquercetin

Cohort B and Cohort C will take isoquercetin

OTHERPlacebo

Placebo


Locations(8)

Beth Israel Deaconess Medical Center (Data Collection Only)

Boston, Massachusetts, United States

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)

Basking Ridge, New Jersey, United States

Memorial Sloan Kettering Monmouth (All Protocol Activities)

Middletown, New Jersey, United States

Memorial Sloan Kettering Bergen (All Protocol Activities)

Montvale, New Jersey, United States

Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities )

Commack, New York, United States

Memorial Sloan Kettering Westchester (All Protocol Activities)

Harrison, New York, United States

Memorial Sloan Kettering Cancer Center (All Protocol Activites)

New York, New York, United States

Memorial Sloan Kettering Nassau (All protocol activities)

Rockville Centre, New York, United States

View Full Details on ClinicalTrials.gov

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NCT07303894


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