CAR T-cell Therapy Targeting CD19 and BCMA in Patients With B Cell Mediated Autoimmune Disease

This study tests a type of immune cell therapy called CAR T-cell therapy — which retrains your own immune cells to attack disease — for people with severe autoimmune diseases caused by B cells (immune cells that mistakenly attack the body). **You may be eligible if...** - You have a confirmed B cell-mediated autoimmune disease (such as lupus, myasthenia gravis, or certain types of inflammatory arthritis) - Your blood counts, liver, kidney, and heart function meet minimum safety thresholds - You have not responded adequately to standard treatments **You may NOT be eligible if...** - Your organ function is too impaired (outside the acceptable range) - You have an active serious infection - You have certain other conditions your doctor would assess Talk to your doctor to see if this trial is right for you.