RecruitingNCT07305922

Delayed Cerebral Infarction Beyond Endoluminal Spasmolysis and Induced Hypertension


Sponsor

Region Stockholm

Enrollment

200 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

An observational study of patients with emerging or established severe cerebral vasospasm after subarachnoid haemorrhage, employing multimodal neuromonitoring.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study examines what happens when the standard treatments for brain artery spasms after a brain bleed (subarachnoid haemorrhage) fail — specifically, how often patients still develop brain infarctions (areas of brain tissue damage) and what factors predict this outcome. **You may be eligible if...** - You are 18 years or older - You are receiving critical care after a subarachnoid haemorrhage (bleeding around the brain) - The source of the bleed (a brain aneurysm) has been treated (either by surgery or a minimally invasive procedure) - You are experiencing suspected or confirmed severe cerebral vasospasm (dangerous narrowing of brain arteries) **You may NOT be eligible if...** - Your expected survival is less than five days - Your Transcranial Doppler ultrasound signal is too weak to measure - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGInduced hypertension with norepinephrine

Induced hypertension with norepinephrine and/or dobutamine to attain clinically established goals of cerebral perfusion pressure in a stepwise fashion, according to clinical routine.

DRUGEndoluminal Spasmolysis

Endoluminal spasmolysis of cerebral arteries using i.a. Nimodipine, according to clinical protocol and neurointerventionist discretion.


Locations(1)

Karolinska University Hospital

Stockholm, Sweden

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NCT07305922


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