RecruitingNCT07305922
Delayed Cerebral Infarction Beyond Endoluminal Spasmolysis and Induced Hypertension
Sponsor
Region Stockholm
Enrollment
200 participants
Start Date
Dec 1, 2025
Study Type
OBSERVATIONAL
Conditions
Summary
An observational study of patients with emerging or established severe cerebral vasospasm after subarachnoid haemorrhage, employing multimodal neuromonitoring.
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- Adults 18 years or older
- Critical care after subarachnoid haemorrhage
- Aneurysm secured by surgical clipping or endovascular procedure
- Suspected, emerging or established severe cerebral vasospasm
Exclusion Criteria3
- Anticipated survival less than five days, as determined by treating clinician
- Transcranial Doppler signal too weak
- Pregnancy
Interventions
DRUGInduced hypertension with norepinephrine
Induced hypertension with norepinephrine and/or dobutamine to attain clinically established goals of cerebral perfusion pressure in a stepwise fashion, according to clinical routine.
DRUGEndoluminal Spasmolysis
Endoluminal spasmolysis of cerebral arteries using i.a. Nimodipine, according to clinical protocol and neurointerventionist discretion.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07305922