RecruitingNot ApplicableNCT07306104

The Effect of Long-term Daily Stimulation of the Brain With Pulsed Electromagnetic Fields on Parkinsons Disease

The Effect of Long-term Treatment of Parkinson's Disease With T-PEMF


Sponsor

University of Southern Denmark

Enrollment

90 participants

Start Date

Feb 16, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn to what extent daily stimulation of the brain with transcranial pulsed electromagnetic fields (T-PEMF) works to treat persons with Parkinson's Disease. The main questions it aims to answer are: * How does 6 months of daily treatment (30 minutes/day) with T-PEMF affects neuro-mechanical and molecular biological factors compared with placebo treatment in persons with Parkinson's disease? * How does 12 months of daily treatment (30 minutes/day) with T-PEMF affects neuro-mechanical and molecular biological factors in persons with Parkinson's disease an does 12 months of T-PEMF alters the need for medication intake? The neuro-mechanical outcomes are compared with the "natural" progression of the disease as well as with a healthy reference group. Furthermore, it will be examined whether 12 months of T-PEMF treatment alters the need for medication intake. Participants in the intervention group will: * receive one 30 min treatment session daily for 12 months * receive either T-PEMF or sham treatment for the first 6 months * receive active T-PEMF treatment the last 6 months * visit for tests before treatment initiation, after 6 months of treatment and after 12 months of treatment.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether daily, long-term use of a wearable device that delivers pulsed electromagnetic fields (PEMF) to the brain can reduce Parkinson's disease symptoms over time. **You may be eligible if...** - You have been diagnosed with idiopathic Parkinson's disease (the most common form, not caused by another condition) - Your Parkinson's symptoms in the medicated state are at stage 1 or 2 on the Hoehn & Yahr scale (mild to moderate) - You scored above 22 on a standard cognitive test (Mini-Mental State Examination), showing reasonable cognitive function - You are able to understand and complete the planned procedures **You may NOT be eligible if...** - You have cancer in the brain, neck, or head - You have an active medical implant (like a pacemaker or deep brain stimulator) - You have epilepsy, severe psychiatric illness, alcoholism, or substance abuse - You have an open wound on your scalp Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETranscranial pulsed electromagnetic fields (T-PEMF)

30 min daily stimulation with transcranial pulsed electromagnetic fields (50 Hz)

DEVICESham (No Treatment)

30 min daily the participants are using/wearing the T-PEMF device but no stimulation occurs


Locations(2)

Odense University Hospital

Odense, Denmark

University of Southern Denmark

Odense, Denmark

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NCT07306104


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