RecruitingNot ApplicableNCT07309354

Tizanidine and Acoustic Reflex

The Effects of Tizanidine on Acoustic Reflex

Sponsor

Uşak University

Enrollment

45 participants

Start Date

Jul 15, 2025

Study Type

INTERVENTIONAL

Conditions

Reflex, Acoustic Hearing

Summary

The goal of this clinical trial is to learn how the muscle relaxant tizanidine affects the acoustic reflex in adults. The acoustic reflex is a natural protection system of the ear that helps reduce the impact of loud sounds. It is not known whether tizanidine changes how this reflex works. The main question this study aims to answer is: Does taking tizanidine for 1 week change acoustic reflex thresholds in the same person, when comparing before and after treatment? Participants who receive tizanidine will undergo hearing and acoustic reflex tests before treatment and again at the end of the treatment period.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria6

Voluntary participation and ability to provide informed consent
Age 18 years or older
Currently receiving tizanidine 6 mg once daily as part of clinical care
No active middle ear disease that could affect tympanometric or acoustic reflex measurements
No chronic neuromuscular disease
Ability to complete audiological testing

Exclusion Criteria7

Refusal to participate
Withdrawal of consent at any time
Age under 18 years
Presence of any ear condition that affects the acoustic reflex (e.g., otitis media, tympanic membrane perforation, otosclerosis)
Presence of chronic neuromuscular disease
Current alcohol or substance use disorder
Any condition preventing completion of acoustic reflex or tympanometry testing

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Interventions

DRUGTizanidine

Participants will receive tizanidine 6 mg orally once daily for 1 week. Standardized audiological testing, including tympanometry and multifrequency acoustic reflex measurements, will be performed before starting treatment and on day 7 at the end of the treatment period to evaluate changes in acoustic reflex thresholds and response patterns.