MPR for Stroke Risk Assessment of ICAS
MRI-Derived Pressure Ratio: a Novel Noninvasive Hemodynamic Biomarker for Stroke Risk Stratification in Intracranial Atherosclerotic Stenosis
Xuanwu Hospital, Beijing
400 participants
Dec 1, 2025
OBSERVATIONAL
Conditions
Summary
Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve prediction. In this multiple prospective registry study we aim to investigate whether regional hemodynamics, measured by a novel Magnetic resonance imaging-derived Pressure Ratio (MPR) technique, are associated with stroke risk in ICAS.
Eligibility
Inclusion Criteria4
- Adults aged 18 to 80 years.
- Intracranial atherosclerotic stenosis ICAS involving a culprit artery in the anterior circulation.
- Intracranial arterial stenosis of 50% to 99% as measured by the WASID method using TCD, CTA, MRA, or DSA.
- Written informed consent obtained from the participant or a legal representative.
Exclusion Criteria5
- Non-atherosclerotic intracranial lesions, including moyamoya disease, vasculitis, vascular dissection, autoimmune diseases, or congenital/genetic abnormalities.
- More than 50% stenosis of the extracranial carotid artery on the ipsilateral side.
- Large cerebral infarction involving more than one-half of the territory on DWI imaging, or a baseline modified Rankin Scale score ≥3.
- Contraindications to antiplatelet therapy or statins.
- Inability to undergo MRI due to metal implants or claustrophobia.
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Interventions
Dual antiplatelet treatment and management of vascular risk factors, in accordance with AHA/ASA guidelines
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07309718