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RecruitingNCT07309718

MPR for Stroke Risk Assessment of ICAS

MRI-Derived Pressure Ratio: a Novel Noninvasive Hemodynamic Biomarker for Stroke Risk Stratification in Intracranial Atherosclerotic Stenosis

Sponsor

Xuanwu Hospital, Beijing

Enrollment

400 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Stroke, IschemicICAS - Intracranial AtherosclerosisHemodynamic

Summary

Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve prediction. In this multiple prospective registry study we aim to investigate whether regional hemodynamics, measured by a novel Magnetic resonance imaging-derived Pressure Ratio (MPR) technique, are associated with stroke risk in ICAS.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Standardized medical therapy targeting vascular risk factors and stroke prevention for people with hemodynamic, icas - intracranial atherosclerosis, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGStandardized medical therapy targeting vascular risk factors and stroke prevention

Dual antiplatelet treatment and management of vascular risk factors, in accordance with AHA/ASA guidelines

Locations(1)

Department of Neurosurgery, Xuanwu hospital

Beijing, Xicheng District, China

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NCT07309718

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