Predicting the Pain Outcome of Surgery for Endometriosis
University of Oxford
100 participants
Dec 1, 2025
OBSERVATIONAL
Conditions
Summary
This study aims to determine whether the investigators can predict who will get benefit in terms of their pain from surgery for more severe forms of endometriosis. The investigators will use brain imaging to explore this, as it allows meaningful results from a smaller sample of people than if questionnaires alone were relied on.
Eligibility
Inclusion Criteria9
- willing and able to give informed consent
- aged between 18 and 50 years of age
- female or born female
- diagnosed with stage III or IV endometriosis by scan (MRI or USS) or previous surgery
- surgical treatment of severe endometriosis planned (surgical procedure at discretion of operating surgeon)
- reports pelvic pain of ≥4/10 (measured using a 0 - 10 numerical rating scale asking about the participant's worst pelvic pain associated with their endometriosis)
- reasonably fluent in English
- in the Investigator's opinion, is able and willing to comply with all study requirements
- willing to allow his or her General Practitioner and consultant to be notified of participation in the study
Exclusion Criteria2
- pregnant, lactating or planning pregnancy during the course of the study
- contraindication to MRI
Interventions
This is an observational study and thus the surgery performed is part of standard clinical care. The procedure will be at the discretion of the operating surgeon/endometriosis multi-disciplinary team and may include bowel resection, stoma formation, ureteric stenting/reimplantation, salpingectomy, oophorectomy or hysterectomy in addition to excision/ablation of endometriosis lesions. Information about the surgical procedure will be collected, but no planned surgical procedure will be an exclusion.
Locations(1)
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NCT07313345