RecruitingPhase 2NCT07316023

Antimicrobial Photodynamic Therapy With ICG-Loaded Nanoparticles for Periodontitis Management

Efficacy of Antimicrobial Photodynamic Therapy Using Polymeric Nanoparticles Loaded With Indocyanine Green in Management of Periodontitis.(A Randomized Controlled Clinical Trial Study With Microbiological Analysis )


Sponsor

Nada Mahmoud Soliman

Enrollment

27 participants

Start Date

Jan 15, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

To better understand and treat your gum disease, dentists now use a system that stages its severity and grades its speed, rather than using old labels. The recommended first step is almost always a deep cleaning, which is very effective. However, because some bacteria can hide from cleanings and antibiotics, researchers are exploring a promising light-based treatment. This method uses a safe, light-activated dye and a gentle laser to target and kill bacteria without leading to resistance. To make this treatment even stronger, scientists are testing a way to package the dye inside tiny, biodegradable "containers" that deliver it directly to the germs. The goal of this research is to see if this advanced delivery method works better than the dye alone, hoping to provide a more powerful, non-surgical option to fight gum disease and protect your teeth."


Eligibility

Min Age: 36 YearsMax Age: 50 Years

Inclusion Criteria1

  • - Both genders aged between 36-50 years (Wadhwa et al., 2021) 2- Generalized stage III grade B periodontitis (Papapanou et al., 2018). Posterior teeth, stage III with PD>6 mm and CAL ≥5 mm 3- Patients ready to comply with oral hygiene measures. 4- Patients free from any systemic disease that may affect the treatment (Glick et al., 2008)

Exclusion Criteria6

  • Smokers
  • Pregnant females.
  • Drug abusers.
  • Patients taking antibiotics or performed any periodontal treatment in the previous 6 months.
  • Justification for Exclusions:
  • To reduce any confounding factors and bias that may affect the results of this study.

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Interventions

DRUGNon- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded nanoparticles

Supragingival scaling and subgingival debridement followed by placement of ICG-loaded nanoparticles activated by diode laser for antibacterial photodynamic therapy to effectively target and eliminate pathogenic bacteria.

DRUGNon- surgical periodontal therapy followed by photodynamic therapy with ICG-loaded macroparticles

supragingival scaling and subgingival debridement followed by ICG-loaded macroparticles activated by diode laser for antibacterial photodynamic therapy to effectively target and eliminate pathogenic bacteria.

OTHERNon- surgical periodontal therapy only

supragingival scaling and subgingival debridement only


Locations(1)

Faculty of Dentistry , Ainshams University

Cairo, Egypt

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NCT07316023


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