Correlation Between Vaspin Gene Polymorphism and Serum Vaspin Levels in Psoriasis Vulgaris
Correlation Between Vaspin Gene Polymorphism and Serum Vaspin Levels in Psoriasis Vulgaris and Its Relation to Pathogenesis and Risk of the Disease
Aswan University
60 participants
Aug 10, 2025
OBSERVATIONAL
Conditions
Summary
Psoriasis is a common immune-mediated inflammatory skin disease affecting at least 100 million individuals worldwide. In Egypt, the prevalence of psoriasis ranges between 0.19% and 3% of the Egyptian people. It is associated with poor quality of life, reduced life expectancy and multimorbidity including psoriatic arthritis, obesity and cardiovascular disease. Vaspin (VASP, SERPIN 12) is a recently discovered adipokine that has been isolated from the visceral adipose tissue of a rat model of type 2 diabetes. It is coded by the gene SERPNA12 located on the long arm of chromosome 14q32.13 and consists of six exons and five introns.
Eligibility
Plain Language Summary
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Interventions
to detect the correlation between vaspin gene polymorphism and serum vaspin levels among psoriasis patients. * To detect the relationship between the risk of psoriasis and the vaspin gene polymorphism. * To detect correlation between vaspin gene polymorphism and the severity of psoriasis.
Locations(1)
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NCT07320872