RecruitingNot ApplicableNCT07323043

Comparison of Cough Response Between Tegilidine and Sufentanil as Pre-induction Agents in General Anesthesia

The Affiliated Lianyungang Hospital of Xuzhou Medical University

Sponsor

The First People's Hospital of Lianyungang

Enrollment

190 participants

Start Date

Jan 15, 2026

Study Type

INTERVENTIONAL

Conditions

General Anesthetic Drug Adverse Reaction

Summary

In patients undergoing general anesthesia with planned tracheal intubation , a prospective, randomized, controlled, double-blind study was conducted to record the occurrence of cough 2 minutes after injection of Sufentanil or tegilidine. The cough was graded based on the frequency and duration: Grade I, no cough; Grade II, a single mild cough; Grade III, multiple coughs with duration \<1 second; Grade IV, continuous coughing with a duration \>15 seconds.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria3

Age between 18 and 65 years, 18 ≤ BMI (kg/m²) ≤ 30;
ASA grade I \~ III;
Scheduled elective surgery under general anesthesia with tracheal intubation.

Exclusion Criteria3

Patients with chronic cough (cough lasting \>8 weeks) or asthma;
Patients with a history of allergy to the drugs used during the study;
Patients with severe cardiovascular disease, intracranial lesions, eye lesions, or lung lesions.

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