RecruitingPhase 2Phase 3NCT07323329

Growth Hormone and Dehydroepiandrosterone Role in Vitro Fertilization

Growth Hormone and Dehydroepiandrosterone Effect on Poor Ovarian Reserve Patients During in Vitro Fertilization


Sponsor

Beni-Suef University

Enrollment

165 participants

Start Date

Oct 10, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to evaluate the role of Somatropin and Dehydroepiandrosterone (DHEA) on ovarian reserve parameters and intracytoplasmic sperm injection (ICSI) outcome in poor ovarian responder. The main question it aims to answer is: Which intervention is more effective in increasing number and size of follicles? Participants will be followed 1 month before starting induction in growth hormone and 12 weeks for DHEA and through intracytoplasmic sperm injection (ICSI) cycle.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 35 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether adding growth hormone and DHEA (a hormone that declines with age) to an IVF (in vitro fertilization) cycle can improve outcomes for women who have a poor ovarian response — meaning their ovaries don't produce many eggs when stimulated. **You may be eligible if...** - You have poor ovarian reserve, meaning at least two of the following apply: you are over 40, you produced 3 or fewer eggs in a previous IVF cycle, your egg count (antral follicle count) is very low, or your AMH hormone level is below the normal threshold **You may NOT be eligible if...** - You have a hormonal or metabolic disorder (like high prolactin, diabetes, or a thyroid problem) - You have a pelvic condition that could affect the IVF process (like hydrosalpinx or a uterine abnormality) - Your partner has severe sperm problems (very low count, poor movement, or abnormal shape) that would prevent fertilization Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSomatropin (4IU for 1 month) plus, folic acid 400 mcg per day.

Patients will receive Somatropin (4IU for 1 month)1 S.C injection every 3 days for at least 1 month plus, folic acid 400 mcg per day.

DRUGDHEA plus folic acid 400mcg per day

Patients will receive DHEA 50 mg twice per day for 12 weeks plus folic acid 400mcg per day

DIETARY_SUPPLEMENTcontrol group

Patients will receive folic acid 400 mcg per day


Locations(1)

Beni-Suef University Hospital

Banī Suwayf, Beni Suweif Governorate, Egypt

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NCT07323329


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