Correlation Between Advanced Glycation End Products and Gastric Motility Disorder in Diabetes Gastroparesis
The Role and Mechanism of SphK1/S1P/FOXO1 Axis Regulating KATP Channel Mediated Gastric Smooth Muscle Dysfunction in Diabetes Gastroparesis
Northern Jiangsu People's Hospital
50 participants
Jan 7, 2026
OBSERVATIONAL
Conditions
Summary
This study is a prospective observational study. The study will explore the correlation between advanced glycation end products and gastric motility disorder in diabetic gastroparesis（DGP) through the collection of blood and gastric tissue samples and relevant data of patients with DGP and control group patients without diabetes history and gastroparesis symptoms.
Eligibility
Inclusion Criteria8
- Meet the diagnostic criteria for diabetes
- Presence of symptoms (see assessment of Gastroparesis Cardinal Symptom Index)
- Age range from 18 to 75 years old
- Voluntarily participate and sign an informed consent form
- No history of diabetes
- No symptoms (see assessment of Gastroparesis Cardinal Symptom Index)
- Age range from 18 to 75 years old
- Voluntarily participate and sign an informed consent form
Exclusion Criteria5
- Currently taking prokinetic drugs, anticholinergic drugs, and dopamine drugs that may affect gastric motility
- Has a history of gastrointestinal surgery
- Pregnant or preparing to conceive
- There are neurological disorders such as Parkinson's disease that affect gastrointestinal function
- Outlet obstruction caused by organic lesions in the pylorus
Interested in this trial?
Get notified about updates and connect with the research team.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07324785