RecruitingNot ApplicableNCT07325058

Tonic Pain and Transauricular Vagal Nerve Stimulation

Exploration of the Effect, and Their Duration, of Different Frequency Transcutaneous Auricular Vagal Nerve Stimulation on Sensory Perception.

Sponsor

Aalborg University

Enrollment

36 participants

Start Date

Dec 18, 2025

Study Type

INTERVENTIONAL

Conditions

Experimental Pain in Healthy Human Subjects

Summary

This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception. Primary outcomes include pain intensity. Secondary outcomes include sensory thresholds, resting heart rate (EKG), pupillary measurements and conditioned pain modulation.

Eligibility

Min Age: 16 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Earlobe Stimulation, a medical device called Sham (No Treatment), and others for people with experimental pain in healthy human subjects. The study is currently recruiting participants at 1 location. People eligible for this study include aged 16 Years to 60 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEtaVNS

Two-headed ball-point electrode which is placed in the concha cymba.

DEVICEEarlobe Stimulation

Circular urface adhering electrodes will be attached to either facet of the earlobe.

DEVICESham (No Treatment)

Circular surface adhesive electrodes will be placed on either facet of the earlobe. No current will pass through the electrodes.

Locations(1)

Center For Neuroplasticity and Pain

Aalborg, Denmark

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NCT07325058