RecruitingPhase 1Phase 2NCT07325136

A Study to Assess the Safety and Tolerability of BMS-986525 Alone and in Combination With Nivolumab in Participants With Relapsed/Refractory Small Cell Lung Cancer

A Phase 1/2 Study of BMS-986525 as Monotherapy and in Combination With Nivolumab in Participants With Relapsed/Refractory Small Cell Lung Cancer


Sponsor

Bristol-Myers Squibb

Enrollment

240 participants

Start Date

Feb 3, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to assess the safety and tolerability of BMS-986525 alone and in combination with Nivolumab in participants with Relapsed/Refractory Small Cell Lung Cancer


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This early-phase study is testing a new drug called BMS-986525, alone and in combination with nivolumab (an immunotherapy), for people with small cell lung cancer (SCLC) that has relapsed (come back) or stopped responding to prior treatment. SCLC is an aggressive form of lung cancer, and new options are urgently needed. **You may be eligible if...** - You have been confirmed to have relapsed or refractory small cell lung cancer (by biopsy or pathology) - You have received at least one platinum-based chemotherapy regimen - If the standard of care in your country includes immunotherapy with chemotherapy, you must have already received that or been ineligible for it **You may NOT be eligible if...** - You have untreated brain metastases (brain tumors that haven't been treated) - You have an active autoimmune disease - You have had an organ or tissue transplant from another person Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBMS-986525

Specified dose on specified days

DRUGNivolumab

Specified dose on specified days


Locations(11)

Local Institution - 0011

Detroit, Michigan, United States

Local Institution - 0026

Buffalo, New York, United States

Local Institution - 0005

Durham, North Carolina, United States

University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States

SCRI Oncology Partners

Nashville, Tennessee, United States

Local Institution - 0001

Rozzano, Milano, Italy

Local Institution - 0020

Hirakata, Osaka, Japan

Local Institution - 0018

Chuo-ku, Tokyo, Japan

Local Institution - 0023

Timișoara, Timiș County, Romania

Local Institution - 0003

Craiova, Romania

Local Institution - 0009

Madrid, Spain

View Full Details on ClinicalTrials.gov

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NCT07325136


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