RecruitingNot ApplicableNCT07325513

Machine Learning in Guiding rTMS Treatment for GWI-Related Headaches and Body Pain


Sponsor

Veterans Medical Research Foundation

Enrollment

140 participants

Start Date

Mar 25, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to create a machine learning algorithm to improve active repetitive transcranial magnetic stimulation (rTMS) treatments for veterans and/or active military personnel by alleviating Gulf War Illness related headaches and body pain (GWI-HAP). This study aims to develop and validate a Support Vector Machine (SVM) model that could replace the trial-and-error process by assessing functional connectivity provided by resting state functional magnetic resonance imaging (rs-fMRI) data to predict the most effective rTMS protocol for each person. All participants will be receiving active rTMS treatment. The main questions it intends to answer are: 1. Does the SVM model predict a more effective treatment response rate for predicted respondents undergoing active rTMS at the left dorsolateral prefrontal cortex (DLPFC) compared to predicted non-respondents? 2. Does the SVM model predict a more effective treatment response rate while undergoing active rTMS at the left dorsolateral prefrontal cortex (DLPFC) and left motor cortex (LMC) in predicted respondents compared to predicted non-respondents? Participants will undergo the following: 1. Receive a total of 13 active rTMS treatment sessions over 3-4 months. 2. Visit the clinic for a total of 15 visits for assessments, check ups, and treatments. 3. Keep a daily log of their headaches, muscle and joint pain throughout the study.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Active Repetitive Transcranial Magnetic Stimulation, a medical device called Active Repetitive Transcranial Magnetic Stimulation, and others for people with gulf war illness, headache, and other related conditions. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEActive Repetitive Transcranial Magnetic Stimulation

rTMS will be administered to the LDLPFC with an active coil.

DEVICEActive Repetitive Transcranial Magnetic Stimulation

rTMS will be administered to the LDLPFC with an active coil.

DEVICEActive Repetitive Transcranial Magnetic Stimulation

rTMS will be administered to the LDLPFC and LMC with an active coil.

DEVICEActive Repetitive Transcranial Magnetic Stimulation

rTMS will be administered to the LDLPFC and LMC with an active coil.


Locations(1)

Jennifer Moreno Department of Veterans Affairs Medical Center

San Diego, California, United States

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NCT07325513


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