Hypofractionated Radiotherapy With a Focal Microboost for High-Risk and Locally Advanced Prostate Cancer

This study is testing a focused form of radiation therapy for men with high-risk or locally advanced prostate cancer. The treatment delivers a concentrated "microboost" of radiation to the most active area of the tumor, aiming to kill cancer more effectively while minimizing damage to surrounding tissue. **You may be eligible if...** - You are a male aged 18 or older - You have high-risk or very high-risk prostate cancer that has not yet spread to distant sites - Your cancer has not been previously treated with radiation, surgery, or similar therapies - You have at least one visible tumor area on MRI that can be targeted - You are able to receive long-term hormone therapy (12–36 months) as part of standard care - Your blood counts and organ function are within acceptable ranges **You may NOT be eligible if...** - Your cancer has spread beyond the pelvis - You have had previous pelvic radiation - You have had a full prostatectomy or other definitive prostate procedures - You are currently taking testosterone supplements - You have a life expectancy of less than 5 years - You have another active cancer (with exceptions for cancers cleared for 5+ years) Talk to your doctor to see if this trial is right for you.