Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies

This study aims to improve how doctors predict whether a patient's cancer will respond to immunotherapy — a treatment that uses the body's own immune system to fight cancer. Researchers will analyze fresh tumor biopsy samples in the lab to identify markers that predict treatment response before therapy begins. **You may be eligible if...** - You are 18 or older - You have a suspected or confirmed cancer diagnosis and are scheduled for a biopsy - If you are newly diagnosed with cancer, you have not yet started any treatment - If you have previously treated cancer, your biopsy will be done before your next line of treatment begins **You may NOT be eligible if...** - You have a known autoimmune disease, prior organ transplant, or chronic kidney or liver disease that would make you ineligible for immunotherapy - You have severely weakened immunity (for example, from HIV, organ transplant, or immunosuppressant medications) - You are pregnant Talk to your doctor to see if this trial is right for you.