Outcomes After Laparoscopic Versus Open Pancreaticoduodenectomy

This study is comparing two surgical approaches for removing part of the pancreas and nearby structures (called a Whipple procedure or pancreaticoduodenectomy): a laparoscopic (keyhole) approach versus traditional open surgery. Researchers want to determine whether the less invasive keyhole approach leads to better recovery outcomes. **You may be eligible if...** - You are 18 or older - You have a confirmed or suspected tumor of the pancreatic head, bile duct, small intestine, or ampulla (where the bile duct meets the intestine) - Your tumor is considered removable based on pre-operative imaging - You are in adequate general health and are able to give informed consent **You may NOT be eligible if...** - Your surgery is an emergency - You have had prior pancreatic surgery - Your cancer has spread to distant organs or cannot be removed - You have a serious cardiovascular or breathing condition that makes major surgery unsafe - You are pregnant - You need a total pancreatic removal, or a different type of pancreatic surgery Talk to your doctor to see if this trial is right for you.