Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury
Tamas Vegh, MD
30 participants
Dec 1, 2023
OBSERVATIONAL
Conditions
Summary
The aim of this study is to longitudinally monitor dynamic changes in the gut microbiome following severe burn injury using fecal samples. Under standard nutritional protocols and intensive care management, serial fecal sampling is performed to assess alterations in microbiome diversity and composition, as well as the indirect effects of these changes on measurable inflammatory biomarkers, endocrine, hematological, immunological, and other organ-specific parameters, the clinical course, and patient outcomes.
Eligibility
Inclusion Criteria3
- Adult patients (age between 18 and 65 years) meeting the diagnostic criteria for severe burn injury, burns involving more than 20% of the total body surface area (TBSA) and/or inhalation injury.
- Burn injury caused by scalding, flame, electrical, contact, or chemical exposure
- Hospital admission within 24 hours following injury
Exclusion Criteria3
- Patients with inflammatory bowel diseases or malignant neoplasms.
- Patients with a history of major gastric and/or intestinal resections
- Patients in a pre-injury ECOG performance status of 4.
Interested in this trial?
Get notified about updates and connect with the research team.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07329595